ChemicalBook > CAS DataBase List > 5-([1,1'-biphenyl]-4-ylmethylene)-2-[4-(2-hydroxyethyl)-1-piperazinyl]-1,3-thiazol-4(5H)-one

5-([1,1'-biphenyl]-4-ylmethylene)-2-[4-(2-hydroxyethyl)-1-piperazinyl]-1,3-thiazol-4(5H)-one

Product Name
5-([1,1'-biphenyl]-4-ylmethylene)-2-[4-(2-hydroxyethyl)-1-piperazinyl]-1,3-thiazol-4(5H)-one
CAS No.
678158-55-9
Chemical Name
5-([1,1'-biphenyl]-4-ylmethylene)-2-[4-(2-hydroxyethyl)-1-piperazinyl]-1,3-thiazol-4(5H)-one
Synonyms
CLZ-8;Mcl1-IN-8;Mcl-1-Puma inhibitor 8;Mcl-1-IN-8,Mcl1IN8,Mcl1 IN 8;4(5H)-Thiazolone, 5-([1,1'-biphenyl]-4-ylmethylene)-2-[4-(2-hydroxyethyl)-1-piperazinyl]-;5-([1,1'-biphenyl]-4-ylmethylene)-2-[4-(2-hydroxyethyl)-1-piperazinyl]-1,3-thiazol-4(5H)-one
CBNumber
CB52056936
Molecular Formula
C22H23N3O2S
Formula Weight
393.5
MOL File
678158-55-9.mol
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5-([1,1'-biphenyl]-4-ylmethylene)-2-[4-(2-hydroxyethyl)-1-piperazinyl]-1,3-thiazol-4(5H)-one Property

Boiling point:
596.6±60.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 50 mg/mL (127.06 mM)
pka
14.96±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals
Product number
DC20444
Product name
Mcl-1-Pumainhibitor8
Purity
>98%
Packaging
100mg
Price
$700
Updated
2021/12/16
DC Chemicals
Product number
DC20444
Product name
Mcl-1-Pumainhibitor8
Purity
>98%
Packaging
250mg
Price
$1400
Updated
2021/12/16
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5-([1,1'-biphenyl]-4-ylmethylene)-2-[4-(2-hydroxyethyl)-1-piperazinyl]-1,3-thiazol-4(5H)-one Chemical Properties,Usage,Production

Description

Mcl-1-PUMA modulator-8 is a modulator of Mcl-1-PUMA interaction which suppresses cancer cells and inhibits PUMA-dependent apoptosis of non-cancerous cells.

5-([1,1'-biphenyl]-4-ylmethylene)-2-[4-(2-hydroxyethyl)-1-piperazinyl]-1,3-thiazol-4(5H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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5-([1,1'-biphenyl]-4-ylmethylene)-2-[4-(2-hydroxyethyl)-1-piperazinyl]-1,3-thiazol-4(5H)-one Suppliers

678158-55-9, 5-([1,1'-biphenyl]-4-ylmethylene)-2-[4-(2-hydroxyethyl)-1-piperazinyl]-1,3-thiazol-4(5H)-oneRelated Search:


  • 5-([1,1'-biphenyl]-4-ylmethylene)-2-[4-(2-hydroxyethyl)-1-piperazinyl]-1,3-thiazol-4(5H)-one
  • Mcl1-IN-8
  • Mcl-1-Puma inhibitor 8
  • Mcl-1-IN-8,Mcl1IN8,Mcl1 IN 8
  • 4(5H)-Thiazolone, 5-([1,1'-biphenyl]-4-ylmethylene)-2-[4-(2-hydroxyethyl)-1-piperazinyl]-
  • CLZ-8
  • 678158-55-9